1. The role of BCG vaccines at birth against Cov2.
2. HIV pts with high VL's contributing to mutations of CoV2.
Regarding the immunopathology, what I've seen with my own eyes(Not research papers or stats) is its somewhat skewed towards people with hyper immune response/obeseity.
Immunocompromised indivduals i.e HIV, patients with autoimmune diseases(SLE, Sarcoidosis etc) on high dose corticosteroid tend to fair Covid just as a normal healthy adult. Most people with S.Covid during the first wave (2020) and Delta wave were all obese and ending in ICU with CK storms.
Haven't looked into BCG at birth at all. The US does not like BCG because it values the skin test over the questionable efficacy of BCG.
Yeah, HIV patients and other immunocompromised people (including elderly, esp with comorbidities) could facilitate the emergence of new SARS-CoV2 mutants. Main issues are time to virus clearance, and time infectious. Anything that extends the first gives the virus time to mutate.
Obesity definitely made it worse. Whether that's impaired immune system not fully clearing the virus, or overactive immune system causing extra damage isn't entirely clear yet.
Great write up. Whats your opinion on:
1. The role of BCG vaccines at birth against Cov2.
2. HIV pts with high VL's contributing to mutations of CoV2.
Regarding the immunopathology, what I've seen with my own eyes(Not research papers or stats) is its somewhat skewed towards people with hyper immune response/obeseity.
Immunocompromised indivduals i.e HIV, patients with autoimmune diseases(SLE, Sarcoidosis etc) on high dose corticosteroid tend to fair Covid just as a normal healthy adult. Most people with S.Covid during the first wave (2020) and Delta wave were all obese and ending in ICU with CK storms.
Haven't looked into BCG at birth at all. The US does not like BCG because it values the skin test over the questionable efficacy of BCG.
Yeah, HIV patients and other immunocompromised people (including elderly, esp with comorbidities) could facilitate the emergence of new SARS-CoV2 mutants. Main issues are time to virus clearance, and time infectious. Anything that extends the first gives the virus time to mutate.
Obesity definitely made it worse. Whether that's impaired immune system not fully clearing the virus, or overactive immune system causing extra damage isn't entirely clear yet.